Our Gut-Brain Axis Laboratory investigates how the gut-brain connection influences brain health, with a particular focus on the neurovascular unit (NVU)—the essential interface of the blood-brain barrier where nutrient delivery and waste clearance occur. As the structural and functional foundation of brain homeostasis, the NVU is central to our work.

Our team uses advanced imaging, molecular, and functional techniques to study the NVU across a wide range of neurological conditions, including stroke, traumatic brain injury, intracerebral hemorrhage/bleeding, neurodegenerative diseases, and tumors. Increasingly, our research explores how gut-derived signals, especially microbial metabolites, modulate NVU function and resilience under stress.

By integrating basic science with translational efforts, we aim to uncover novel mechanisms of brain injury and protection—ultimately driving the development of new therapies and clinical interventions that improve outcomes for patients affected by brain disease.

Advancing Discovery at the Blood-Brain Barrier

We are a multidisciplinary team of physicians, scientists, trainees, and research staff driven by a shared mission: to transform our understanding of the brain by exploring how external influences—such as the gut microbiome—affect the blood-brain barrier and the broader neurovascular unit. Our work is grounded in rigorous, hypothesis-driven science with a strong emphasis on translation to clinical impact.

Fostering a Culture of Excellence

We cultivate a collaborative, dynamic, and intellectually vibrant environment. Committed to scientific excellence, we aim to set the benchmark for translational neurosurgical research through innovation, teamwork, and high-impact discovery.

Mentoring the Next Generation of Scientists

Training and supporting emerging scientists is central to our mission. We take pride in mentoring students, residents, fellows, and early-career researchers, empowering them to become thoughtful, independent investigators. Our team’s passion for discovery and dedication to patient care define who we are—and we hope to inspire the next generation to build upon this legacy.

Upholding the Highest Standards of Integrity

We believe that diverse perspectives and unwavering scientific integrity are essential to meaningful progress. Our research is conducted with transparency, honesty, and accountability. We embrace rigorous peer review, open dialogue, and ethical responsibility in every aspect of our work.